Payloads in Global Drug-Conjugates Pipelines
In 1910, Paul Ehrlich first proposed the concept of “magic bullets” and postulate that some compounds could directly access to some desired targets in cell to cure diseases.[1] With the effective therapeutic results of the antibody-drug conjugates, various approaches have been investigated to achieve a selective delivery of different effector molecules to cancer cells.
Structure of Drug-Conjugates
In principle, all conjugates used for selective drug delivery consist of three modules. The first component is the carrier, which facilitates tumor targeting. The second component is the drug itself, which can induce a variety of biological functions. The third module links the former two. (Fig.1)
The heart of every drug-conjugates is the payload. While the carrier and the linker structure provide the selectivity, the payload is the component that facilitates the actual purpose of the drug-conjugates. Herein we analyzed and summarized the layout of the global payloads as below according to the drug-conjugates in the pipelines.
Selective Drug Conjugates
Fig. 1 Schematic structure of receptor targeting drug conjugates.[2]
Overview of Payloads in the Drug-Conjugates Pipeline
Fig. 2 Overview of Payloads in the Drug-Conjugates Pipeline
Payloads Distribution in Different Clinical Phase
Fig.3 Payloads Distribution in Different Clinical Phase
Note: Please contact us for the pipeline list when you are interested the detail information.
References
[1] N. Engl. J. Med. 2004, 11, 1079.
[2] Frontiers in Chemistry 2020, 8, 571