Payload And Linker Synthesis

The development of antibody-drug conjugates (ADCs) has significantly been advanced in the past decade given the improvement of payloads, linkers and conjugation methods. Payload linker (also known as drug-linker, toxin-linker or linker-payload) architecture is fundamental to the successful design of your drug candidate. ChemExpress has decades of expertise in custom synthesis, specializing in complex and novel linker-payload variants and chemical moieties, offering fully customized Linker-Payload Synthesis services to meet the specific needs of client projects.

With a deep expertise in target biology and extensive experience in custom payload-linkers, we assist clients in selecting the most effective payload-linker combinations to maximize therapeutic efficacy. Our skilled team supports the entire development process, from early-stage discovery to clinical candidate identification, ensuring precision and efficiency at every stage. In addition to our custom services, ChemExpress boasts a robust inventory of payloads and linkers, complemented by significant experience in linker compound synthesis. This enables us to deliver ADC small molecules in quantities ranging from milligrams to kilograms.

ChemExpress End-to-End Payload-Linker Service

To date, we've supported over 800 clients in developing their ADC projects and completed more than 150 ADC projects. As a trusted partner, we bring unparalleled expertise in Payload-Linker Synthesis, offering innovative solutions and robust technical support for the successful development of bioconjugate therapeutics. With our extensive inventory of payloads and linkers and a cutting-edge synthetic chemistry platform, ChemExpress offers customized payload-assembling services about tailored drug-linker solutions, optimizing each combination based on specific chemical requirements, and offer comprehensive ADC linker-payload Synthesis services.

1
Extensive experience in linker compound synthesis, with over 1000 successful syntheses
2
We provide custom synthesis and modification of ADC linkers, designing and optimizing chemical linkers to enhance compatibility, performance, and overall ADC efficiency.
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We specialize in the custom synthesis and modification of ADC payloads, optimizing both new and existing payloads to meet precise project requirements.
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Offering synthesis, and structural modification of drug-linker conjugates for ADCs, optimizing both new and existing conjugates for superior performance.

ChemExpress delivers a comprehensive range of payload and linker services, including high-quality drug linker synthesis, Advanced technologies and methodologies, and Good Manufacturing Practice (GMP) manufacturing. Leveraging our expertise in ADC development& manufacturing and innovative linker technologies, supported by state-of-the-art facilities, we create highly effective, custom-tailored ADCs for targeted therapies. Discover how our solutions can advance your projects by contacting us today.

Technical Advantages

In-depth experience supports synthesis within the new modality field
Thorough strategies for chiral control and the preparation of chiral impurities
Strategies for addressing the instability of ADC small molecule products
Comprehensive and professional software support for genotoxicity research
Cutting-edge single crystal cultivation and structure analysis technologies
Quality research practices aligned with the principles of QbD

Our teams have extensive expertise in identifying, optimizing, and commercializing chemical payloads and linkers, as well as designing proprietary synthetic routes. We've developed advanced precursors to accelerate common payload synthesis with reduced risk and offer a diverse range of payloads. Our experience also includes the design, synthesis, and SAR development of ADC payloads, including:

Microtubulin inhibitors: MMAE, MMAD, MMAF, DM1, DM4
Targeting DNA payloads: PBD
Enzyme inhibitors: Dxd, SN38, Exatecan

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We offer a comprehensive in-stock ADC linkers, along with customized linker solutions and design services tailored to specific needs. ChemExpress provide one-stop ADC linker development services, including linker design, synthesis, characterization and optimization.

Cleavable linkers
Enzyme cleavable linkers
Non-cleavable linkers

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Partner with ChemExpress

ChemExpress offers one stop end-to-end CDMO service solutions for Antibodies and ADCs, providing antibodies, payload linkers, conjugates and drug products to biotech & pharma from R&D to commercialization, ensuring high quality and efficiency across the development and production of antibody, payloads, linkers, and extensive experience in linker compound synthesis. Our facilities include R&D laboratories, kilogram-scale GMP plants and commercial-scale GMP manufacturing plants. This enables us to provide end-to-end project support from discovery to commercialization.

Let’s talk about how to smooth the path for your next ADC project.

80+ Payloads

400+ Linkers

1000+ Linker Syntheses
Large-scale payloads and
linkers GMP manufacturing
Advanced technologies
and methodologies
50+ CMC Projects,

1 Commercial Project
12 sec-DMFs,
offering High-quality and cost-effective products
Passed US FDA inspection
with zero 483 observations
Integrated ADC DS & DP CDMO
platform for commercialization

Payload-Linker Intermediates

Preclinical
Phase I
Phase II
Phase III
Commercial

Payload-Linker Intermediates

XDC
Conjugation

Milligram

Linker-Payloads Screen, Process Development and Optimization, Custom Synthesis

Gram

Kilogram

10-100Kg

Payload-Linker Intermediates

XDC
Conjugation

Quick Response Fast Delivery
Full-lifecycle CMC support
Quality by Design：Continuous Optimization and Improvement
Rich Experience Dedicated & Reliable
Cost-effective Stable supply

Related services

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ChemExpress ADC Products handbook (ADC)

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