High-Throughput Experimentation (HTE)
ChemExpress has established High-Throughput Experimentation (HTE) platform to keep up with the increasing demand of pharmaceutical timelines in drug discovery and development. HTE is a powerful tool that allows the execution of large numbers of experiments in parallel while requiring limited material and less effort per-experiment. Taking these advantages, we are able to optimize individual steps in a total synthesis for solving complex chemical problems.

Reaction types
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Metal-catalyzed cross coupling, Pd-carbonylation, C-H activiation, RCM, etc.
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Heterogeneous hydrogenation, Asymmetric (transfer) hydrogenation
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Bases, acids or Lewis acids catalyzed capability
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Amide-formation
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Chiral acids/bases resolution
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Metal scavenger screening, salt-formation and crystalline polymorphs identification
HTE-Capabilities
- Reaction development and optimization
- Class variable screening
- Catalyst Screening
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Highly automated DoE
(in progress)
- Work-up development
- Scavenger screening
- High-throughput extraction
- Crystallization development
- Solid form and synthetic intermediate crystallization screening
- Late-phase solubility