High-Throughput Experimentation (HTE)
High-Throughput Experimentation (HTE) offers key advantages in minimal material consumption, high experimental efficiency, and broad exploration capacity. By evaluating multiple reaction parameters in parallel with minimal starting material, it effectively addresses complex chemistry challenges encountered in R&D and scale-up production.
ChemExpress’ HTE platform provides mg-scale condition screening and g-scale validation, with a monthly throughput exceeding 3,000 reactions. This significantly accelerates project timelines and enhances R&D efficiency.
Our Capability
ChemExpress’ HTE platform integrates advanced instruments for reaction screening, parallel reactions, and high-throughput analysis, enabling systematic evaluation of hundreds to thousands of conditions with minimal material input.
Screened Reaction Types
- Metal-Catalyzed Cross Coupling
- Homo- or Heterogeneous Hydrogenation, Asymmetric
(transfer) Hydrogenation - Bases, Acids or Lewis Acids Catalysis
- Amide-formation, RCM, Carbonylation
- Chiral Acids/Bases Resolution
- Metal Scavenger Screening, Salt-Formation and Crystalline Polymorphs Identification
Why Partner With ChemExpress
Extensive Project Experience
240+ optimized screening conditions have been applied in production scale-up projects at the 100-gram scale and above, shortening process development cycles by 20–40% and significantly reducing the material and time costs associated with traditional trial-and-error approaches
Advanced Technologies
Supporting 8–96 parallel experiments at 1–40 mL scale, with a temperature range of -35°C to 180°C and pressure tolerance up to 6 MPa
Comprehensive Reaction Coverage
Supports a broad range of reaction types, including transition metal catalysis and asymmetric synthesis, enabling efficient scale-up condition screening and optimization to help improve yields and reduce process costs
Key Equipment
FAQs
High-throughput parallel reaction screening enables simultaneous evaluation of multiple reaction conditions in a single experiment, significantly accelerating condition optimization compared to traditional one-at-a-time approaches. It reduces material consumption, shortens development timelines, and improves the reliability of scale-up outcomes.
High-throughput experimentation is broadly applicable and particularly well-suited for condition-sensitive reactions such as transition metal catalysis, asymmetric synthesis, redox reactions, and cross coupling. Leveraging advanced instrumentation and a team of R&D experts with nearly a decade of experience in chemical process development and high-throughput catalytic reaction screening, ChemExpress’ HTE platform provides robust condition screening and scale-up across diverse and complex reaction systems.
