Nucleosides, a basic chemical for amidites to support oligonucleotide development
2′-fluoro (2′-F) substitutions may be regarded as starting points for oligonucleotide therapies, since oligonucleotides with these modifications constitute versatile, synthetic analogs of the naturally occurring counterparts. 2'-fluoro-2'-deoxy nucleosides are used in many synthetic oligonucleotides, since they increase binding affinity to the complementary target and also provide protective effects[1].Consequently, they exhibit excellent chemical and enzymatic stability[2]. With the rapid emergence of oligonucleotide drugs, 2'-fluoro-2'-deoxy nucleosides have gained significant importance as crucial raw materials for such drugs, leading to a rapid growth in market demand.
ChemExpress is as an oligonucleotide CRO&CDMO service partner. Currently, we are capable of providing several nucleosides, including 2'-fluoro-2'-deoxyadenosine, 2'-fluoro-2'-deoxycytidine, and 2'-fluoro-2'-deoxyuridine, along with their derivatives. ChemExpress has already achieved a supply capacity of tons and can provide products of stable production capacity and excellent quality.
Reference：
[1] Hum Gene Ther. 2015.26(8):475-85.
[2] Nucleic Acids Research. 2019, 3306–3320
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