One-Stop ADC
CDMO Service
ChemExpress offers integrated services spanning from Payload-Linker to ADC DS&DP, enabling efficient scale-up and seamless technology transfer, effectively reducing management and transition costs.
Extensive Project Experience
& Comprehensive Inventory
Over 80 CMC projects, 6 BLA projects, and 1 commercial project have been delivered. 16 ADC payloads and related intermediates are registered with the FDA as DMFs.
Expert Scientific
Team
Our team of over 700 scientists provides comprehensive support from R&D to commercialization, ensuring high-quality, scalable solutions for your ADC pipeline.
Our Services
With deep expertise in the ADC payload linker field, ChemExpress has built a solid foundation in R&D, and has accumulated extensive experience on over 2,000 linker synthesis experience.
Our Service Scope Includes
- Custom ADC Linker Synthesis and Optimization
- Custom ADC Payload Synthesis and Optimization
- Custom ADC Payload-Linker Synthesis
- Structural Characterization
- Non-GMP & GMP Manufacturing
- Genotoxic Impurity Assessment
- Chiral Impurity Control
- Stability Study
- Regulatory Registration Strategy & Support
Why Partner with ChemExpress
Comprehensive End-to-End Solutions
Over 150 payloads in stock, over 500 linkers in stock, and over 2,000 linker syntheses experience, enabling the management of ADC Payload-Linker CMC challenges from R&D to commercialization, and providing a seamless, one-stop service to accelerate market entry
Professional Team
An ADC payload-linker team of over 500 professional experts，with average of around 10+ years of pharmaceutical industry experience among our R&D managements
Comprehensive Analysis
Integrated analytical platform combining advanced instrumentation and scientific expertise, comprehensive genotoxicity research and thorough strategies for chiral control, advanced structural characterization for reliable product identity, purity, and safety assurance
Our Sites
R&D Sites
ADC Payload-Linker and Conjugation R&D, Route Confirmation, Process Optimization and GLP Toxicological Batch Production. 
ADC Payload-Linkers & HPAPIs Process Development and Manufacturing.
Related Services
ADC Payload
Our facilities support Non-GMP & GMP payload production scales from milligram to kilogram with over 150 payloads in stock to meet diverse needs across every stage of ADC development and manufacturing.
ADC Linker
ChemExpress collaborates closely with clients to ADC linker screen, customized synthesis, process development & optimization, clinical supply, and commercial manufacturing to support advanced research worldwide.
Case Study
We enabled the development and launch of RC48,
the first Chinese developed and approved ADC drug.
FAQs
Based on our typical project experience, we provide the following estimated timeline for your reference and planning:
· Process Optimization & GLP Production: 3 - 4 months.
Includes optimizing the synthesis route, impurity study and synthesis, GLP batch production, and RSM preparation for clinical batches.
· Process Transfer & Technical Package Preparation: 1 month.
Includes synthetic technical package, analytical technical package, inactivation strategy, and process safety assessment.
· GMP manufacturing Preparation & Execution: 1 - 2 months.
Includes production scheduling, material procurement, GMP manufacturing, and release testing.
· Registration Documentation Preparation: 1 - 2 months post-GMP production.
The registration team will intervene early to collect data and draft the submission documents..
Yes. We offer integrated ADC payload-linker manufacturing from preclinical development through GMP clinical supply and commercial production. The HPAPI facilities are equipped with negative pressure isolators to meet operation requirements of the most toxic highly potent APIs (OEB5, OEL 0.01μg/m3 ).
Integrated production minimizes supply chain complexity, reduces technology transfer interfaces, and improves batch-to-batch consistency, supporting a streamlined CMC strategy.
