Biocatalysis
Biocatalysis utilizes enzymes or whole cells as catalysts to drive highly efficient and selective chemical transformations. Compared to conventional chemical synthesis, biocatalytic processes offer distinct advantages, including mild reaction conditions, high selectivity, environmental sustainability, and cost-effectiveness, making them a well-established approach for the synthesis of pharmaceuticals and key intermediates.
ChemExpress' biocatalysis platform offers a one-stop solution, including enzyme discovery, enzyme screening, enzyme directed evolution, and biocatalytic process optimization etc. With scalable manufacturing support ranging from hundreds of grams to hundreds of kilograms, we empower clients to accelerate the transition from R&D to commercialization.
What We Can offer
- Enzyme Discovery and Development
- High-Throughput Screening of Enzyme Libraries
- Enzyme Directed Evolution
- Scalable Biocatalytic Process Development
- Pilot and Commercial Scale-Up
Enzyme Library
- Ketoreductase (KRED)
- Transaminases (ATA)
- Hydrolases (HLE)
- Ene-reductases (ERED)
- α-Ketoglutarate-Dependent Oxygenases (α-KGO)
- Imine reductases (IRED)
- Cyclohexanone Monooxygenases (CHMO)
- Amine Dehydrogenases (AmDH)
- Phenylalanine Ammonia-Lyases (PAL)
Backed by a library of 1000+ enzymes, ChemExpress is experienced in handling all common biocatalytic reactions.
Why Partner With ChemExpress
One-Stop Biocatalysis Solutions
From enzyme screening and directed evolution to process development and commercial production, ChemExpress provides fully integrated biocatalysis services across the entire lifecycle
Extensive Enzyme Library & Rapid Screening
With a library of 1000+ enzymes and the HTE capabilities, ChemExpress delivers initial screening results within 1–2 working days
Flexible & Scalable Manufacturing
ChemExpress’ production facilities support reliable scale-up from hundreds of grams to hundreds of kilograms, accommodating projects at every stage
Green Chemistry & Sustainability
Leveraging the high specificity and stereoselectivity of enzymes, our biocatalytic processes reduce side reactions and impurities at the source, delivering high-purity products under mild, environmentally responsible conditions — supporting sustainable development
Key Equipment
Case Study
Dynamic Kinetic Resolution (DKR)
Background : The starting material is a racemic mixture containing a single chiral center, while the desired product requires two chiral centers. Traditional chemical resolution is limited to a theoretical yield of 25%, presenting significant challenges in both efficiency and cost.
Achievement : Through targeted enzyme library screening, ChemExpress developed a DKR process and successfully scaled it to kilogram-level production of Compound A, delivering:
· Conversion rate of >95%
· Target configuration selectivity of 93% (7% isomers)
· 50% reduction in process cost
· 2 fewer synthetic steps
FAQs
Four key advantages:
(a) High stereoselectivity (ee ≥99%) with minimal by-products formation;
(b) Mild reaction conditions (20-50°C), eliminating the need for high temperature/pressure or flammable solvents;
(c) Enzymes from microbial fermentation are more cost-effective than precious metal catalysts;
(d) Environmentally friendly, compliant with ESG.
With 1000+ enzymes in our library, ChemExpress’ biocatalysis platform supports ketone reductions, transaminations, hydrolyses and other common reactions.
Immobilized enzymes offer reusability, high stability, and simplified product separation. Compatible with new technologies such as flow chemistry and electrochemistry, this technology has been successfully applied in hundred-kilogram scale production, reducing overall costs.
