Key Chiral Intermediates Assist in the Production of Avibactam Sodium
Zavicefta® is an intravenously administered combination of the third-generation cephalosporin Ceftazidime and the novel, non-β-lactam β-lactamase inhibitor Avibactam Sodium. It has good therapeutic effects in anti-infection, representing a valuable new treatment option for these serious and difficult-to-treat infections[1]. The sales of Zavicefta were approximately $550 million in 2022, which shows promising prospects in the field of anti-infection.
The Advantages of Using Key Chiral Intermediates
The use of key chiral intermediates can effectively reduce the challenge of handling chirality in the synthesis of Avibactam Sodium, enhancing synthesis efficiency and facilitating scale-up production.
ChemExpress is capable of providing key chiral intermediates of Avibactam Sodium with mature technology, stable supply and production capacity of tons.
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Reference:
[1] Drugs. 2018, 78, 675–692
[2] US20120323010